Tissue Lysates
Cayman Chemical SynthetIc GosypetIn 1mg
A flavonoid with diverse biological activities; inhibits MKK3 and MKK6, as well as induces apoptosis and cell cycle arrest at the G2 phase in KYSE-450 and KYSE-510 esophageal cancer cells at 20 µM; scavenges DPPH radicals and inhibits copper-induced lipid peroxidation in cell-free assays; reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis at 10 mg/kg
Cayman Chemical FumonIsIn B3 1mg
A mycotoxin; cytotoxic to primary rat hepatocytes at 125, 250, and 500 µM; induces hepatocyte nodules in rats at 0.05% in the diet for 14 or 21 days; has been detected in corn and corn-based foods and livestock feeds
Cayman Chemical FSlRY-amIde 1mg
A peptide antagonist of PAR2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2; does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein; used to study PAR2 action in cells and in animals
Cayman Chemical SynthetIc OSW-1 1mg
A saponin with antiviral and anticancer activities; an inhibitor of OSBP and its paralog ORP4 (Kis = 16 and 71 nM in radioligand binding assays using HEK293T cell lysates); inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM); inhibits replication of CVB3 in infected HeLa R19 cells in an OSBP-dependent manner at 3 nM; protects against CVA9 and echovirus 2 infection in HeLa cells at 10 nM; inhibits replication of HCV but not MHV, a coronavirus; inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively)
Cayman Chemical SynthetIc AvIcularIn 1mg
A flavonoid glycoside with diverse biological activities; inhibits FASN and aldose reductase (IC50s = 6.15 and 19.05 µM for the chicken liver and human enzymes, respectively); scavenges DPPH and superoxide radicals, as well as inhibits copper-induced oxidation of LDL in cell-free assays (IC50s = 64.3, 6, and 3.8 µM, respectively); inhibits LPS-induced increases in NO and PGE2 production in RAW 264.7 macrophages at 30-300 µM; inhibits the proliferation, migration, and invasion of, as well as induces apoptosis and cell cycle arrest at the G0/G1 phase in, Huh7 cells at 100 UG/ml
Cayman Chemical 13acetyl9DIhydrobaccatIn I 1mg
A taxane with anticancer activity; inhibits proliferation of P388 leukemia cells (IC50 = 20 μg/ml)
Cayman Chemical SIamycIn I 1mg
A tricyclic peptide with antiviral and antibacterial activities; active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro; inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells (ED50 = 0.08 μM); active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml); inhibits GBAP-induced autophosphorylation of the E. faecalis quorum sensing kinase FsrC
Cayman Chemical TrIs 4 7dIphenyl1 10phen 1mg
A luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen; strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time
Cayman Chemical BD 1008hydrobromIde 1mg
A selective antagonist of the σ1 receptor (Ki = 2 nM) that displays 4-fold selectivity for σ1 over σ2; used to modulate signaling through σ receptors by cocaine and in models of learning and memory impairment
Cayman Chemical BaohuosIde I 1mg
A flavonoid; inhibits human recombinant PDE5A1 (IC50 = 0.16 μM) in a cell-free assay; protects PC12 rat adrenal cells from hydrogen peroxide-induced death at 25 μM; inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively); decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a STZ-induced rat model of neurodegeneration at 10 mg/kg per day; increases ICP in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction at 10 mg/kg per day